Table 1.
Gastric solid emptying (%) in different sessions (mean ± SD) (ANOVA P = 0.03)
| Control | Lub 24 µg | Lub 48 µg | Lub 48 µg plus atropine | Atropine | |
|---|---|---|---|---|---|
| 15 min | 1.3 ± 0.6 | 1.3 ± 0.4 | 2.2 ± 0.5* | 0.3 ± 0.1* | 0.2 ± 0.1* |
| 30 min | 6.9 ± 2.2 | 7.5 ± 3.8 | 13.0 ± 3.7* | 1.6 ± 0.8* | 0.8 ± 0.2* |
| 45 min | 15.5 ± 4.3 | 17.6 ± 5.6 | 23.8 ± 4.9* | 3.4 ± 1.5* | 2.2 ± 0.7* |
| 60 min | 25.6 ± 6.5 | 28 ± 7.5 | 37.6 ± 7.0* | 6.8 ± 2.8* | 3.7 ± 0.7* |
| 90 min | 42.6 ± 7.4 | 45 ± 10.6 | 58.6 ± 8.4* | 13.8 ± 5.1* | 9.8 ± 2.3* |
| 120 min | 53.1 ± 5.8 | 59.9 ± 9.4 | 72.2 ± 7.7* | 24.7 ± 7.7* | 24.1 ± 6.0* |
| 150 min | 64.0 ± 5.6 | 69.4 ± 7.5 | 79.6 ± 6.8* | 39.1 ± 8.7* | 42.9 ± 8.6* |
| 180 min | 68.9 ± 6.6 | 74.9 ± 6.6 | 83.3 ± 6.6* | 53.4 ± 9.5* | 54.9 ± 9.6* |
Footnotes: Lub = lubiprostone;
*
P < 0.05 vs. Control; P > 0.05: atropine session vs. atropine plus lubiprostone 48 µg at any time points; P < 0.05 Control, lubiprostone 24 µg, atropine, lubiprostone 48 µg plus atropine vs. lubiprostone 48 µg at any time points.