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. 2015 May 30;15:218. doi: 10.1186/s12879-015-0962-4

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© Fabri et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Antigen-specific responses among the broader population. Sera from multiple groups were analyzed for antibodies against a. LID-1 (IgG); b. NDO-LID (IgG and IgM); c. NDO-HSA (IgM) and d. PGL-I (IgM). Each point represents the EI of an individual serum sample, with the total number of participants in each group noted below. The mean EI is represented by the horizontal line. The traced horizontal line is threshold for determining a positive result (EI = 1.1). a: IgG against LID-1: Patients versus HHCs versus Gpop, difference not significant (H = 0.57; p = 0.753). b: IgG and IgM against NDOLID: Patients versus HHCs versus Gpop (H = 31.37). Mann–Whitney U test with Bonferroni correction: Patients versus HHCs (p < 0.0001); Patients versus GPop (p < 0.0001); HHCs versus GPop * mean EI of the GPop group was greater than the mean EI of the HHCs group (p < 0.0001). c: IgM against NDOHSA: Patients versus HHCs versus GPop (H = 50.66). Mann–Whitney U test with Bonferroni correction: Patients versus HHCs (p < 0.0001); Patients versus GPop (p = 0.013); HHCs versus GPop * mean EI of the EC group was greater than the mean EI of the HHCs group (p < 0.0001). d: IgM against PGL-1: Patients versus HHCs (U = 1769; p < 0.0001)