Table 1.
Epitope prediction by BIMAS algorithm: estimated binding affinities of Aβ-derived nonamers to various HLA molecules
| HLA molecule | Start AA position | Nonamer peptide | BIMAS scorea |
|---|---|---|---|
| A1 | 20 | VFFAEDVGS | 18 |
| A02.01 | 16 | KLVFFAEDV | 453 |
| 33 | GLMVGGVVI | 15 | |
| A02.05 | 31 | IIGLMVGGV | 6 |
| A24 | 9 | GYEVHHQKL | 396 |
| A3 | 16 | KLVFFAEDV | 2 |
| A11.01 | - | - | - |
| A31.01 | - | - | - |
| A33.02 | 7 | DSGYEVHHQ | 1.5 |
| A68.01 | 24 | VGSNKGAII | 24 |
| B14 | 4 | FRHDSGYEV | 4 |
| B27.02 | 4 | FRHDSGYEV | 20 |
| 2 | AEFRHDSGY | 15 | |
| B27.05 | 4 | FRHDSGYEV | 600 |
| 2 | AEFRHDSGY | 75 | |
| 15 | QKLVFFAED | 27 | |
| 8 | SGYEVHHQK | 25 | |
| B28.01 | - | - | - |
| B35.01 | 26 | SNKGAIIGL | 3 |
| B37.01 | - | - | - |
| B38.01 | 12 | VHHQKLVFF | 30 |
| B39.01 | - | - | - |
| B39.02 | 27 | NKGAIIGLM | 12 |
| B40 | 2 | AEFRHDSGY | 32 |
| 10 | YEVHHQKLV | 16 | |
| B44.03 | 2 | AEFRHDSGY | 240 |
| B51.01 | 24 | VGSNKGAII | 104 |
| 32 | IGLMVGGVV | 57 | |
| 28 | KGAIIGLMV | 24 | |
| B51.02 | 33 | GLMVGGVVI | 132 |
| 24 | VGSNKGAII | 88 | |
| 28 | KGAIIGLMV | 28 | |
| B51.03 | 32 | IGLMVGGVV | 52 |
| 24 | VGSNKGAII | 48 | |
| 28 | KGAIIGLMV | 40 | |
| B52.01 | 32 | IGLMVGGVV | 300 |
| 24 | VGSNKGAII | 75 | |
| 28 | KGAIIGLMV | 36 | |
| B62 | 32 | IGLMVGGVV | 5 |
| B7 | 26 | SNKGAIIGL | 4 |
| B8 | 26 | SNKGAIIGL | 4 |
aEstimated half time of dissociation of corresponding MHC/peptide complexes, using BIMAS algorithm. Values above significant affinity threshold are depicted in italic