Study	Reason for exclusion
Cai 1999	Not a RCT: Case series.
Chang 1997	Not a RCT: Case series.
Che 1987	Quasi-RCT. Odd and even numbers used for allocation.
Che 1990	Not a RCT: Controlled clinical trial.
Chen 1989	Not a RCT: Field trial.
Fleckenstein 2007	Not a RCT: Controlled clinical trial evaluating drug pharmacokinetics.
Huang 1988	Quasi-RCT. Randomized according to order of admission.
Huang 1989	Quasi-RCT. Odd and even numbers used for allocation. Compared plain and enteric coated tablets of pyronaridine
Huang 1993	RCT: Conducted in people with complicated falciparum malaria (malignant malaria).
Huang 1996	RCT: Compared single dose versus two days of the same drug combination.
Liu 2002	RCT: Compared pyronaridine + dihydroartemisinin versus dihydroartemisinin alone and with pyronaridine alone. No ACT comparator; no data on liver functions provided in report to include for "Adverse event affecting liver functions".
Looareesuwan 1996	Not a RCT: Clinical trial of two doses of pyronaridine monotherapy with group given second dose recruited after results of first dose were analysed.
Looareesuwan 2007	RCT: Phase II dose ranging trial.
NCT01156389	RCT: ongoing trial evaluating drug interactions in healthy volunteers.
No authors listed 1985	Not a RCT: field trial.
Pang 1989	Not a RCT: controlled clinical trial comparing tablets versus intramuscular injections of pyronaridine/sulfadoxine/pyrimethamine.
Piola 2008	Not a RCT: phase II dose ranging study.
Ramharter 2008	Quasi-RCT. Sequential allocation; Phase II dose ranging trial.
Shao 1991	Not a RCT: case series.
Tan 2008	Not a RCT: Pharmacokinetic study in healthy volunteers.
Wattanavijitkul 2008	Not a RCT: Pharmacokinetic study in healthy volunteers.