Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Total failure (Day 28)	2		Risk Ratio (M-H, Fixed, 95% CI)	Subtotals only
1.1 PCR-unadjusted	2	1720	Risk Ratio (M-H, Fixed, 95% CI)	0.60 [0.40, 0.90]
1.2 PCR-adjusted	2	1650	Risk Ratio (M-H, Fixed, 95% CI)	1.69 [0.56, 5.10]
2 Total failure (Day 42)	2		Risk Ratio (M-H, Random, 95% CI)	Subtotals only
2.1 PCR-unadjusted	2	1691	Risk Ratio (M-H, Random, 95% CI)	0.85 [0.53, 1.36]
2.2 PCR-adjusted	2	1472	Risk Ratio (M-H, Random, 95% CI)	1.53 [0.73, 3.19]
3 Early treatment failure	2	1676	Risk Ratio (M-H, Fixed, 95% CI)	0.74 [0.12, 4.42]
4 Parasite clearance time (hours)	1	1170	Mean Difference (IV, Fixed, 95% CI)	-3.20 [-4.38, -2.02]
5 Fever clearance time (hours)	1	1170	Mean Difference (IV, Fixed, 95% CI)	-1.20 [-2.38, -0.02]
6 Gametocyte clearance time	1	1170	Mean Difference (IV, Fixed, 95% CI)	-10.5 [-12.40, -8.60]
7 Serious adverse events	2	1787	Risk Ratio (M-H, Fixed, 95% CI)	0.92 [0.20, 4.28]
8 Adverse events leading to withdrawal from treatment	2	1787	Risk Ratio (M-H, Fixed, 95% CI)	1.37 [0.67, 2.82]
9 Patient reported symptoms	2		Risk Ratio (M-H, Fixed, 95% CI)	Subtotals only
9.1 Headache	1	1272	Risk Ratio (M-H, Fixed, 95% CI)	0.86 [0.60, 1.24]
9.2 Cough	2	1807	Risk Ratio (M-H, Fixed, 95% CI)	0.85 [0.62, 1.17]
9.3 Abdominal pain	1	1272	Risk Ratio (M-H, Fixed, 95% CI)	1.08 [0.67, 1.75]
9.4 Vomiting	1	535	Risk Ratio (M-H, Fixed, 95% CI)	1.58 [0.73, 3.44]
9.5 Pyrexia	1	535	Risk Ratio (M-H, Fixed, 95% CI)	1.46 [0.67, 3.19]
9.6 Influenza- like illness	1	535	Risk Ratio (M-H, Fixed, 95% CI)	1.20 [0.54, 2.70]
10 Patient reported symptoms judged as drug-related	2		Risk Ratio (M-H, Fixed, 95% CI)	Subtotals only
10.1 Vomiting	2	1807	Risk Ratio (M-H, Fixed, 95% CI)	1.25 [0.68, 2.31]
10.2 Headache	1	1272	Risk Ratio (M-H, Fixed, 95% CI)	1.03 [0.57, 1.85]
10.3 Abdominal pain	1	1272	Risk Ratio (M-H, Fixed, 95% CI)	1.25 [0.60, 2.57]
10.4 Vertigo	1	1272	Risk Ratio (M-H, Fixed, 95% CI)	1.49 [0.48, 4.61]
10.5 Haematuria	1	1272	Risk Ratio (M-H, Fixed, 95% CI)	2.49 [0.55, 11.32]
10.6 Upper abdominal pain	1	1272	Risk Ratio (M-H, Fixed, 95% CI)	1.12 [0.35, 3.62]
10.7 Anorexia	1	1272	Risk Ratio (M-H, Fixed, 95% CI)	0.33 [0.09, 1.17]
11 Abnormal LFTs; grade 3 and 4 toxicity	2		Risk Ratio (M-H, Fixed, 95% CI)	Subtotals only
11.1 Alanine aminotransferase (ALT)	2	1807	Risk Ratio (M-H, Fixed, 95% CI)	2.00 [0.43, 9.42]
11.2 Asparatate aminotransferase (AST)	2	1807	Risk Ratio (M-H, Fixed, 95% CI)	3.85 [0.70, 21.09]
11.3 Alkaline phosphatase (ALP)	1	1272	Risk Ratio (M-H, Fixed, 95% CI)	0.10 [0.00, 2.07]
11.4 Bilirubin	2	1807	Risk Ratio (M-H, Fixed, 95% CI)	1.30 [0.30, 5.62]
12 Change in haemoglobin	2		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
12.1 Haemoglobin at baseline	2	1807	Mean Difference (IV, Fixed, 95% CI)	-0.03 [-0.19, 0.13]
12.2 Haemoglobin day 3	2	1755	Mean Difference (IV, Fixed, 95% CI)	-0.01 [-0.13, 0.11]
12.3 Haemoglobin day 7	2	1741	Mean Difference (IV, Fixed, 95% CI)	-0.16 [-0.28, -0.05]
12.4 Haemoglobin day 28	2	1702	Mean Difference (IV, Fixed, 95% CI)	0.04 [-0.09, 0.18]
13 Anaemia as an adverse event	1		Risk Ratio (M-H, Fixed, 95% CI)	Subtotals only
13.1 Anaemia (AE of any cause)	1	535	Risk Ratio (M-H, Fixed, 95% CI)	1.23 [0.68, 2.23]
13.2 Anaemia (drug- related AE)	1	535	Risk Ratio (M-H, Fixed, 95% CI)	0.69 [0.32, 1.47]