Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Total failure PCR-adjusted (Day 28); subgrouped by age	2		Risk Ratio (M-H, Fixed, 95% CI)	Subtotals only
1.1 Age = 5 years	2	1469	Risk Ratio (M-H, Fixed, 95% CI)	1.01 [0.25, 4.03]
1.2 Age < 5 years	1	216	Risk Ratio (M-H, Fixed, 95% CI)	3.37 [0.43, 26.38]
2 Total failure PCR-adjusted (Day 28); subgrouped by region	2	1675	Risk Ratio (M-H, Fixed, 95% CI)	1.10 [0.44, 2.76]
2.1 West Africa	2	816	Risk Ratio (M-H, Fixed, 95% CI)	1.42 [0.29, 6.92]
2.2 East Africa	2	194	Risk Ratio (M-H, Fixed, 95% CI)	2.64 [0.13, 53.14]
2.3 South-central Africa	2	490	Risk Ratio (M-H, Fixed, 95% CI)	0.67 [0.15, 2.92]
2.4 Asia	2	175	Risk Ratio (M-H, Fixed, 95% CI)	1.02 [0.09, 10.99]
3 Total failure PCR-adjusted (Day 28); subgrouped by country	2	1675	Risk Ratio (M-H, Fixed, 95% CI)	0.94 [0.41, 2.18]
3.1 Burkina Faso	1	25	Risk Ratio (M-H, Fixed, 95% CI)	1.05 [0.05, 22.91]
3.2 DR Congo	2	369	Risk Ratio (M-H, Fixed, 95% CI)	0.5 [0.10, 2.43]
3.3 Gabon	1	78	Risk Ratio (M-H, Fixed, 95% CI)	0.17 [0.01, 4.03]
3.4 Ivory Coast	1	100	Risk Ratio (M-H, Fixed, 95% CI)	2.25 [0.27, 18.43]
3.5 Kenya	2	194	Risk Ratio (M-H, Fixed, 95% CI)	2.64 [0.13, 53.14]
3.6 Mali	2	318	Risk Ratio (M-H, Fixed, 95% CI)	0.0 [0.0, 0.0]
3.7 The Gambia	1	90	Risk Ratio (M-H, Fixed, 95% CI)	0.0 [0.0, 0.0]
3.8 Ghana	1	7	Risk Ratio (M-H, Fixed, 95% CI)	0.0 [0.0, 0.0]
3.9 Mozambique	1	121	Risk Ratio (M-H, Fixed, 95% CI)	1.5 [0.06, 36.02]
3.10 Senegal	1	198	Risk Ratio (M-H, Fixed, 95% CI)	0.0 [0.0, 0.0]
3.11 Phillipines	2	107	Risk Ratio (M-H, Fixed, 95% CI)	0.0 [0.0, 0.0]
3.12 Indonesia	1	68	Risk Ratio (M-H, Fixed, 95% CI)	0.89 [0.09, 9.32]