Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Total failure PCR-unadjusted (Day 28); Sensitivity analysis	2		Risk Ratio (M-H, Fixed, 95% CI)	Subtotals only
1.1 Primary analysis (Cochrane review)	2	1720	Risk Ratio (M-H, Fixed, 95% CI)	0.60 [0.40, 0.90]
1.2 Missing data included as failures	2	1807	Risk Ratio (M-H, Fixed, 95% CI)	0.77 [0.58, 1.03]
1.3 Missing data included as successes	2	1807	Risk Ratio (M-H, Fixed, 95% CI)	0.61 [0.41, 0.90]
1.4 Intention to treat analysis (of trial authors)	2	1807	Risk Ratio (M-H, Fixed, 95% CI)	0.77 [0.58, 1.03]
1.5 Per-protocol analysis (of trial authors)	2	1683	Risk Ratio (M-H, Fixed, 95% CI)	0.66 [0.43, 1.01]
2 Total failure PCR-adjusted (Day 28); Sensitivity analysis	2		Risk Ratio (M-H, Fixed, 95% CI)	Subtotals only
2.1 Primary analysis (Cochrane review)	2	1650	Risk Ratio (M-H, Fixed, 95% CI)	1.69 [0.56, 5.10]
2.2 Missing or indeterminate PCR results included as failures	2	1651	Risk Ratio (M-H, Fixed, 95% CI)	1.35 [0.49, 3.73]
2.3 New infections included as successes	2	1720	Risk Ratio (M-H, Fixed, 95% CI)	1.41 [0.51, 3.88]
2.4 Missing data included as failures	2	1807	Risk Ratio (M-H, Fixed, 95% CI)	1.06 [0.71, 1.57]
2.5 Missing data included as successes	2	1807	Risk Ratio (M-H, Fixed, 95% CI)	1.41 [0.51, 3.89]
2.6 Intention to treat analysis (by trial authors)	2	1807	Risk Ratio (M-H, Fixed, 95% CI)	0.87 [0.60, 1.24]
2.7 Per-protocol analysis (by trial authors)	2	1676	Risk Ratio (M-H, Fixed, 95% CI)	1.38 [0.50, 3.81]