Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Total failure (Day 28)	1		Risk Ratio (M-H, Fixed, 95% CI)	Subtotals only
1.1 PCR-unadjusted	1	1200	Risk Ratio (M-H, Fixed, 95% CI)	0.35 [0.17, 0.73]
1.2 PCR adjusted	1	1187	Risk Ratio (M-H, Fixed, 95% CI)	0.38 [0.14, 1.02]
2 Total failure (Day 42)	1		Risk Ratio (M-H, Fixed, 95% CI)	Subtotals only
2.1 PCR-unadjusted	1	1146	Risk Ratio (M-H, Fixed, 95% CI)	0.86 [0.57, 1.31]
2.2 PCR adjusted	1	1116	Risk Ratio (M-H, Fixed, 95% CI)	1.64 [0.89, 3.00]
3 Early treatment failures	1	1103	Risk Ratio (M-H, Fixed, 95% CI)	0.16 [0.01, 3.96]
4 Parasite clearance time (hours)	1	1259	Mean Difference (IV, Fixed, 95% CI)	-2.60 [-4.94, -0.26]
5 Fever clearance time (hours)	1	1051	Mean Difference (IV, Fixed, 95% CI)	0.10 [-1.52, 1.72]
6 Gametocyte clearance time (hours)	1	27	Mean Difference (IV, Fixed, 95% CI)	-5.40 [-21.80, 11.00]
7 Serious adverse events	1	1271	Risk Ratio (M-H, Fixed, 95% CI)	1.00 [0.25, 3.97]
8 Adverse events leading to withdrawal from treatment	1	1271	Risk Ratio (M-H, Fixed, 95% CI)	0.62 [0.17, 2.31]
9 Patient reported symptoms	1	7626	Risk Ratio (M-H, Fixed, 95% CI)	0.99 [0.80, 1.22]
9.1 Vomiting	1	1271	Risk Ratio (M-H, Fixed, 95% CI)	1.00 [0.45, 2.20]
9.2 Diarrhea	1	1271	Risk Ratio (M-H, Fixed, 95% CI)	0.44 [0.17, 1.14]
9.3 Headache	1	1271	Risk Ratio (M-H, Fixed, 95% CI)	1.15 [0.82, 1.60]
9.4 Dizziness	1	1271	Risk Ratio (M-H, Fixed, 95% CI)	0.46 [0.28, 0.78]
9.5 Cough	1	1271	Risk Ratio (M-H, Fixed, 95% CI)	1.50 [0.74, 3.03]
9.6 Myalgia	1	1271	Risk Ratio (M-H, Fixed, 95% CI)	1.39 [0.83, 2.32]
10 Abnormal LFTs; Grade 2 toxicity	1		Risk Ratio (M-H, Fixed, 95% CI)	Totals not selected
10.1 Alanine aminotransferase (ALT)	1		Risk Ratio (M-H, Fixed, 95% CI)	0.0 [0.0, 0.0]
10.2 Aspartate aminotransferase (AST)	1		Risk Ratio (M-H, Fixed, 95% CI)	0.0 [0.0, 0.0]
10.3 Alkaline phosphatase (ALP)	1		Risk Ratio (M-H, Fixed, 95% CI)	0.0 [0.0, 0.0]
10.4 Bilirubin	1		Risk Ratio (M-H, Fixed, 95% CI)	0.0 [0.0, 0.0]
11 Abnormal LFTs; Grade 3 or 4 toxicity	1		Risk Ratio (M-H, Fixed, 95% CI)	Totals not selected
11.1 Alanine aminotransferase (ALT)	1		Risk Ratio (M-H, Fixed, 95% CI)	0.0 [0.0, 0.0]
11.2 Aspartate aminotransferase (AST)	1		Risk Ratio (M-H, Fixed, 95% CI)	0.0 [0.0, 0.0]
11.3 Alkaline phosphatase (ALP)	1		Risk Ratio (M-H, Fixed, 95% CI)	0.0 [0.0, 0.0]
11.4 Bilirubin	1		Risk Ratio (M-H, Fixed, 95% CI)	0.0 [0.0, 0.0]
12 Haemoglobin (g/dL)	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
12.1 Haemoglobin at baseline	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
12.2 Haemoglobin day 3	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
12.3 Haemoglobin day 7	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
12.4 Haemoglobin day 28	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
13 Platelet counts (x 109/L)	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
13.1 baseline	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
13.2 day 3	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
13.3 day 7	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
13.4 day 28	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
14 White blood counts (x 109/L)	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
14.1 baseline	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
14.2 day 3	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
14.3 day 7	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
14.4 day 28	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
15 Abnormal ECG finding	1	2542	Risk Ratio (M-H, Fixed, 95% CI)	0.58 [0.20, 1.73]
15.1 QT prolongation	1	1271	Risk Ratio (M-H, Fixed, 95% CI)	0.17 [0.02, 1.59]
15.2 ECG abnormalities	1	1271	Risk Ratio (M-H, Fixed, 95% CI)	1.00 [0.25, 3.97]