Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Total failure PCR-adjusted (Day 28); subgrouped by region	1	1117	Risk Ratio (M-H, Fixed, 95% CI)	0.38 [0.14, 1.03]
1.1 East Africa	1	38	Risk Ratio (M-H, Fixed, 95% CI)	0.0 [0.0, 0.0]
1.2 West Africa	1	192	Risk Ratio (M-H, Fixed, 95% CI)	1.48 [0.06, 35.75]
1.3 South central Africa	0	0	Risk Ratio (M-H, Fixed, 95% CI)	0.0 [0.0, 0.0]
1.4 Asia	1	887	Risk Ratio (M-H, Fixed, 95% CI)	0.31 [0.10, 0.93]
2 Total failure PCR-adjusted (Day 28); subgrouped by country	1	1117	Risk Ratio (M-H, Fixed, 95% CI)	0.38 [0.14, 1.03]
2.1 Thailand	1	551	Risk Ratio (M-H, Fixed, 95% CI)	0.12 [0.03, 0.57]
2.2 Vietnam	1	159	Risk Ratio (M-H, Fixed, 95% CI)	0.0 [0.0, 0.0]
2.3 Cambodia	1	132	Risk Ratio (M-H, Fixed, 95% CI)	3.31 [0.17, 62.62]
2.4 India	1	45	Risk Ratio (M-H, Fixed, 95% CI)	0.0 [0.0, 0.0]
2.5 Burkina Faso	1	118	Risk Ratio (M-H, Fixed, 95% CI)	0.0 [0.0, 0.0]
2.6 Ivory Coast	1	74	Risk Ratio (M-H, Fixed, 95% CI)	1.65 [0.07, 39.20]
2.7 Tanzania	1	38	Risk Ratio (M-H, Fixed, 95% CI)	0.0 [0.0, 0.0]