Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Total failure PCR-unadjusted (Day 28); Sensitivity analysis	1		Risk Ratio (M-H, Fixed, 95% CI)	Subtotals only
1.1 Primary analysis (Cochrane review)	1	1200	Risk Ratio (M-H, Fixed, 95% CI)	0.35 [0.17, 0.73]
1.2 Missing data included as failures	1	1271	Risk Ratio (M-H, Fixed, 95% CI)	0.72 [0.49, 1.05]
1.3 Missing data included as successes	1	1271	Risk Ratio (M-H, Fixed, 95% CI)	0.35 [0.17, 0.73]
1.4 Intention to treat analysis (of trial authors)	1	1271	Risk Ratio (M-H, Fixed, 95% CI)	0.72 [0.49, 1.05]
1.5 Per-protocol analysis (of trial authors)	1	1120	Risk Ratio (M-H, Fixed, 95% CI)	0.36 [0.17, 0.78]
2 Total failure PCR-adjusted (Day 28); Sensitivity analysis	1		Risk Ratio (M-H, Fixed, 95% CI)	Subtotals only
2.1 Primary analysis (Cochrane review)	1	1187	Risk Ratio (M-H, Fixed, 95% CI)	0.38 [0.14, 1.02]
2.2 Missing or indeterminate PCR results included as failures	1	1187	Risk Ratio (M-H, Fixed, 95% CI)	0.38 [0.14, 1.02]
2.3 New infections included as successes	1	1200	Risk Ratio (M-H, Fixed, 95% CI)	0.39 [0.15, 1.03]
2.4 Missing data included as failures	1	1271	Risk Ratio (M-H, Fixed, 95% CI)	0.82 [0.54, 1.24]
2.5 Missing data included as successes	1	1271	Risk Ratio (M-H, Fixed, 95% CI)	0.39 [0.15, 1.03]
2.6 Intention to treat analysis (by trial authors)	1	1271	Risk Ratio (M-H, Fixed, 95% CI)	0.76 [0.51, 1.14]
2.7 Per-protocol analysis (by trial authors)	1	1117	Risk Ratio (M-H, Fixed, 95% CI)	0.37 [0.13, 1.05]