Table 7.
Summary of ECG monitoring and results
| Trial ID | Days tested | ECG results | |
| Pyronaridine arm | Comparator arm | ||
| Kayentao 2012 | 0, 2, 7, 14, and 28 |
"no post baseline clinically important ECG results" | "no post baseline clinically important ECG results" |
| Tshefu 2010 | 0, 2, 7, 14, and 28 | 1 patient with T-wave inversion at day 2 1 patient with ventricular premature complexes and extended QTc (manual reading QTcB 461 ms, QTcF 458 ms) at day 21 |
1 patient with sinus bradycardia and sinus arrhythmia on day 2 1 patient with sinus bradycardia on day 2 |
| Rueangweerayut 2012 | Unclear | 6/848 (0.7%) patients with abnormal ECGs- "All were mild and resolved before study completion"1/848 with QT prolongation- None had a QT interval that exceeded 480 msec | 3/423 (0.7%) patients with abnormal ECGs - "All were mild and resolved before study completion" 3/423 with long or prolonged QT interval - None had a QT interval that exceeded 480 msec |
| Poravuth 2011 | 0, 2, 7, 14, and 42 |
1/226 (0.4%) patients with QTc prolongations | 6/222 (2.7%) patients with QTc prolongations (1/222 not drug-related) |