Study characteristics |
|
Patient sampling |
Cross-sectional design with consecutive-based enrolment of participants, prospective data collection |
Patient characteristics and setting |
Country of origin: Georgia
World Bank classification of country: middle/low
Type of lab: reference
Type of patients: confirmed MDR-TB cases
|
Index tests |
Manufacturer involvement: no
Type of testing: direct
|
Target condition and reference standard(s) |
Culture based DST, LJ
FQ: ofloxacin 2 µg/mL
SLIDS: capreomycin 40 µg/mL; kanamycin 30 µg/mL
There was no discrepant analysis
All reported XDR resistance
|
Flow and timing |
Uninterpretable results reported: yes |
Comparative |
|
Notes |
|
Methodological quality |
|
Item |
Authors' judgement |
Risk of bias |
Applicability concerns |
DOMAIN 1: Patient Selection |
|
Was a consecutive or random sample of patients enrolled? |
Yes |
|
|
Was a case-control design avoided? |
Yes |
|
|
Did the study avoid inappropriate exclusions? |
Yes |
|
|
|
|
|
Low |
DOMAIN 2: Index Test All tests |
|
Were the index test results interpreted without knowledge of the results of the reference standard? |
Unclear |
|
|
If a threshold was used, was it pre-specified? |
Yes |
|
|
|
|
|
Unclear |
DOMAIN 3: Reference Standard |
|
Is the reference standards likely to correctly classify the target condition? |
Yes |
|
|
Were the reference standard results interpreted without knowledge of the results of the index tests? |
Unclear |
|
|
|
|
|
Low |
DOMAIN 4: Flow and Timing |
|
Was there an appropriate interval between index test and reference standard? |
Yes |
|
|
Did all patients receive the same reference standard? |
Yes |
|
|
Were all patients included in the analysis? |
Yes |
|
|
|
|
|
|