Vardy 2000

Methods	Individual randomised controlled trials
Participants	Dx: mild to moderate SD of the scalp in persons 15 years of age and older (physician diagnosis stated in article) Excluded: women who are pregnant and lactating, etc
Interventions	Intervention: ciclopirox olamine 1% shampoo applied twice daily to scalp for 28 days (n = 53) Control: placebo shampoo applied similarly (n = 44)
Outcomes	Complete clearance Symptom severity scores for redness, scaling and itching
Notes	Country: Israel; COI: Shampoo was provided by Trima, Israel Pharmaceutical Products; side effects: ciclo (2:53), placebo (1:49)
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No information on randomisation
Allocation concealment (selection bias)	Unclear risk	Not reported
Baseline comparable?	Unclear risk	"No significant differences in age, sex, severity of each symptom, overall severity were found between the 2 groups"
Patient blinded?	Unclear risk	Not reported
Provider blinded?	Unclear risk	Not reported
Outcome assessor blinded?	Unclear risk	Not reported
Co-interventions avoided?	Unclear risk	Not reported
Compliance acceptable?	Unclear risk	Not reported
Drop-out acceptable?	Low risk	Ciclo (6:53), placebo (5:44)
Selective outcome reporting acceptable?	Unclear risk	All outcomes were reported
ITT?	High risk	Totals in result tables show per-protocol analysis