Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Failure to achieve complete resolution	9		Risk Ratio (M-H, Fixed, 95% CI)	Subtotals only
1.1 Studies assessed as having no COI	5	392	Risk Ratio (M-H, Fixed, 95% CI)	0.54 [0.46, 0.64]
1.2 Studies assessed as potentially having COI	4	2167	Risk Ratio (M-H, Fixed, 95% CI)	0.78 [0.73, 0.83]
2 Decrease in erythema score	2		Std. Mean Difference (IV, Random, 95% CI)	Totals not selected
2.1 Studies assessed as potentially having COI	2		Std. Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
3 Decrease in pruritus score	3		Std. Mean Difference (IV, Fixed, 95% CI)	Subtotals only
3.1 Studies assessed as potentially having COI	3	699	Std. Mean Difference (IV, Fixed, 95% CI)	-0.55 [-0.85, -0.26]
4 Side effects	6		Risk Ratio (M-H, Random, 95% CI)	Subtotals only
4.1 Studies assessed as having no COI	2	206	Risk Ratio (M-H, Random, 95% CI)	1.82 [1.07, 3.09]
4.2 Studies assessed as potentially having COI	4	782	Risk Ratio (M-H, Random, 95% CI)	0.75 [0.52, 1.09]