Abeck 2004
| Methods | Individual randomised controlled trials | |
| Participants | Diagnosis: patients with seborrhoeic dermatitis of the scalp (physician's diagnosis implied) with scores of 2 to 4 for scaling and inflammation at baseline Exclusion: persons with psoriasis, atopic dermatitis, long hair; those treated with systemic antibiotics or antifungals 2 weeks or less before commencement of study; pregnancy/breast feeding; child-bearing potential without adequate contraception or irregular menstrual cycles; history of drug or alcohol use; and many others (see Table 1, page 14) Sex: male (109), female (74) |
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| Interventions | Intervention: ciclopirox 1% shampoo applied 3 times weekly for 28 days (n = 45) Controls:
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| Outcomes | Complete clearance | |
| Notes | Country: Germany; conflict of interest: none; side effects: 27 participants overall had side effects, which included skin and appendage disorders, pruritus, mild hair loss, severe parietal erythema and moistness of scalp | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Unclear risk | "Subjects were randomized into four parallel groups ..." |
| Allocation concealment (selection bias) | Unclear risk | Not reported |
| Baseline comparable? | Low risk | "The differences in baseline characteristics among groups were minor and unlikely to affect results" |
| Patient blinded? | Unclear risk | "... randomized, double-blind, vehicle controlled four arm trial ..." |
| Provider blinded? | Unclear risk | "... randomized, double-blind, vehicle controlled four arm trial ..." |
| Outcome assessor blinded? | Unclear risk | "... randomized, double-blind, vehicle controlled four arm trial ..." |
| Co-interventions avoided? | Low risk | "No other cosmetic nor non-cosmetic treatment of the scalp or hair was permitted" |
| Compliance acceptable? | Unclear risk | Not reported |
| Drop-out acceptable? | Unclear risk | Not reported |
| Selective outcome reporting acceptable? | Low risk | All outcomes were reported |
| ITT? | Low risk | "All analyses were performed for the ITT population ..." Results confirm this |