Kousidou 1992

Methods	Individual randomised controlled trials
Participants	Diagnosis: SebDerm Excluded: patients currently on corticosteroids or antibiotics Sex: M (21/40); age (33.7 ± 10.2 years); severity (?)
Interventions	Intervention: ketoconazole cream 2% applied facially once daily for 28 days (n = 20) Control: hydrocortisone cream 1% applied facially once daily for 28 days (n = 20)
Outcomes	Global evaluation of improvement by investigator at 4 weeks Symptom severity score for erythema, scaling and pruritus at 4 weeks
Notes	Country: Greece
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	"They were randomized to two groups?"
Allocation concealment (selection bias)	Unclear risk	Not reported
Baseline comparable?	Low risk	"without any statistically significant difference in mean scores"
Patient blinded?	Unclear risk	Not reported
Provider blinded?	Unclear risk	Not reported
Outcome assessor blinded?	Unclear risk	Not reported
Co-interventions avoided?	Unclear risk	Not reported
Compliance acceptable?	Unclear risk	Not reported
Drop-out acceptable?	Low risk	"One patient in the ketoconazole group stopped treatment after two weeks because of dermatitis"
Selective outcome reporting acceptable?	Low risk	All outcomes reported
ITT?	Low risk	Not reported