Shuttleworth 1998

Methods	Individual randomised controlled trials
Participants	Diagnosis: dandruff diagnosed by a physician. Participant must have dandruff on both sides of the scalp, females must be on contraception Exclusion criteria: allergies to shampoos; pregnancy, lactation; recent use of medication that can affect test shampoo; eye disease that could be exacerbated by study; history of photosensitivity and history of corticosteroid use in the 2 weeks preceding the study
Interventions	Intervention: 1.5% ciclopirox olamine shampoo applied twice weekly to scalp (n = 22) Control 1: unmedicated (placebo) shampoo base applied twice weekly to scalp for 4 weeks (n = 22) Control 2: ketoconazole 2% applied twice weekly to scalp for 4 weeks (n = 22)
Outcomes	Symptom severity score for erythema and scaling
Notes	Country: UK Sponsorship by Stiefel Labs; study was conducted by Pharmaco UK Ltd Adverse effect: scalp irritation in keto group (2/32)
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	"... according to a predetermined randomization schedule"
Allocation concealment (selection bias)	Unclear risk	Not reported
Baseline comparable?	Unclear risk	"The groups were balanced with respect to age, sex, presence of seborrhoeic dermatitis ...." No tabulated data from which to ascertain this
Patient blinded?	Unclear risk	".. double blinded ..."
Provider blinded?	Unclear risk	".. double blinded ..."
Outcome assessor blinded?	Unclear risk	".. double blinded ..."
Co-interventions avoided?	Unclear risk	Not reported
Compliance acceptable?	Unclear risk	Not reported
Drop-out acceptable?	Low risk	".. two subjects failed to complete the study for personal reasons unrelated to the shampoo"
Selective outcome reporting acceptable?	Low risk	All outcomes reported
ITT?	Unclear risk	Not reported