Table 2. Analyses of object-level morphological features regarding 8-DFS.

Variables	Recurrence, n (%)	Median 8-DFS (month)	8-DFS Rate (%)	P value
TNs fractal dimension				0.004
1 (<1.60)	29 (54.7)	90.8	45.3
2 (1.60 - 1.70)	87 (65.9)	52.1	34.1
3 (>1.70)	36 (80.0)	26.0	20.0
TNs number				<0.001
1 (<52.0)	42 (50.6)	90.8	49.4
2 (52.0 - 80.4)	85 (72.0)	42.9	28.0
3 (>80.4)	25 (86.2)	29.3	13.8
TNs perimeter sum				0.001
1 (<25076.04)	30 (51.7)	90.8	48.3
2 (25076.04 - 33151.54)	79 (66.4)	49.9	33.6
3 (>33151.54)	43 (81.1)	29.6	18.9
TNs cell Delaunay area sum				0.007
1 (<1241981.0)	47 (58.0)	82.2	42.0
2(1241981.0 - 1263738.0)	43 (63.2)	45.1	36.8
3 (>1263738.0)	62 (76.5)	34.5	23.5
Stromal cell structure feature				0.011
1 (<26.21)	19 (48.7)	96.0	51.3
2 (26.21 - 32.57)	111 (67.7)	45.3	32.3
3 (>32.57)	22 (81.5)	22.9	18.5
TNs area average				0.011
1 (<9543.71)	89 (73.6)	40.3	26.4
2 (9543.71 - 15615.19)	42 (61.8)	67.2	38.2
3 (>15615.19)	21 (51.2)	90.8	48.8
TNs area variance				0.014
1 (<30965.25)	101 (73.7)	42.2	26.3
2 (30965.25 - 51733.13)	28 (57.1)	78.6	42.9
3 (>51733.13)	23 (52.3)	89.2	47.7
TNs cell nuclei area average				0.04
1 (<190.67)	46 (82.1)	42.7	17.9
2 (190.67 - 213.68)	74 (66.7)	42.9	33.3
3 (>213.68)	32 (50.8)	92.9	49.2
TNs cell nuclei area variance				0.056
1 (<72.80)	21 (84.0)	39.0	16.0
2 (72.80 - 97.75)	100 (65.8)	45.3	34.2
3 (>97.75)	31 (58.5)	87.5	41.5
TNs cell nuclei area eccentricity maximum				0.077
1 (<0.98579)	16 (57.1)	87.3	42.9
2 (0.98579 - 0.99323)	114 (65.9)	52.1	34.1
3 (>0.99323)	22 (75.9)	34.5	24.1

TNs: Cancer cell group with various geometrical and morphological features is called tumor nests (TNs).