Table 4. Multivariate Cox proportional hazards model to predict 8-DFS in 230 IDC patients.
| Variables | Coefficient | Hazard Ratio (95% CI) | P value |
|---|---|---|---|
| T | 0.082 | 1.086 (0.843, 1.399) | 0.524 |
| N | 0.120 | 1.128 (0.947, 1.343) | 0.176 |
| Histologic grade | 0.387 | 1.472 (1.051, 2062) | 0.025 |
| ER | –0.276 | 0.759 (0.543, 1.061) | 0.107 |
| HER2 | 0.658 | 1.931 (1.368, 2.725) | <0.001 |
| TNs fractal dimension | 0.161 | 1.174 (0.830, 1.661) | 0.364 |
| TNs feature | 0.283 | 1.327 (1.001, 1.759) | 0.049 |
| TNs cell Delaunay area sum | 0.182 | 1.200 (0.921, 1.564) | 0.177 |
| TNs cell density | 0.486 | 1.625 (1.177, 2.244) | 0.003 |
| TNs cell nuclei feature | –0.317 | 0.729 (0.537, 0.989) | 0.042 |
| Stroma cell structure feature | 0.467 | 1.596 (1.142, 2.229) | 0.006 |
TNs: tumor nest; HER2: human epidermal growth factor 2; T: tumor; N: node; ER: estrogen receptor.