Table 3.

Summary of studies with association between heart disease and KEGG pathways enriched by miRNA target genes

KEGG pathway	Enrichment P -value	Ref.	Description
Axon guidance	3.61×10−14	[56]	Axon guidance of sympathetic neurons to cardiomyocytes is a promising target for regulation of cardiac function in diseased hearts
Colorectal cancer	1.92×10−10	[57]	Significant association between colorectal neoplasm and coronary artery disease
Chronic myeloid leukaemia	1.92×10−10	[58]	Imatinib mesylate (a therapeutic agent for chronic myeloid leukaemia) has cardiotoxicity
Glutamatergic synapse	3.35×10−9	—	—
Hepatitis B	5.86×10−9	[59]	Hepatitis B virus causes varied forms of heart disease
Pancreatic cancer	6.60×10−9	—	—
Acute myeloid leukaemia	2.54×10−8	[60]	Cause of acute ischemic heart disease
Focal adhesion	6.65×10−8	[61]	Focal adhesion kinase deletion attenuates pressure overload-induced hypertrophy
MAPK signaling pathway	3.50×10−7	[62]	Plays an important role in cardiac and vascular disease pathogenesis
Endometrial cancer	4.55×10−7	[63]	Cardiovascular disease is the leading cause of death among endometrial cancer patients
Chagas disease	6.33×10−7	[64]	Association with heart disease
T cell receptor signaling pathway	9.82×10−7	—	—
ErbB signaling pathway	1.01×10−6	[65]	ErbB-signaling pathway proteins are potential drug targets for heart failure treatment
Prostate cancer	2.47×10−6	[66]	Coronary artery disease and prostate cancer are both common diseases sharing many risk factors
Neurotrophin signaling pathway	3.08×10−6	—	—
Toxoplasmosis	3.16×10−6	[67]	Toxoplasmosis is a cause of heart disease
Bacterial invasion of epithelial cells	3.84×10−6	—	—
TGF-beta signaling pathway	7.35×10−6	[68]	Upregulated in infarcted myocardium
Nonsmall-cell lung cancer	9.00×10−6	—	—
VEGF signaling pathway	1.17×10−5	[69]	A VEGF inhibitor has cardiotoxicity
Dopaminergic synapse	2.19×10−5	[70]	Dopamine agonists affect the cardiovascular system