Table 9.
Summary of studies with association between heart disease and KEGG pathways enriched by BAHSIC identified miRNA target genes
| KEGG pathway | Enrichment P -value | Ref. | Description |
|---|---|---|---|
| Long-term depression | 5.37×10−19 | [71] | Depression has been linked with additional health problems, including heart disease |
| Prion diseases | 3.13×10−17 | [72] | Prion-induced amyloid heart disease with high blood infectivity in transgenic mice |
| Axon guidance | 5.99×10−14 | (Already identified by CPCAFE) | |
| Fatty acid biosynthesis | 2.01×10−12 | [73] | A relationship between fatty acid synthase andcardiac calcium signaling has been suggested |
| Calcium signaling pathway | 2.04×10−10 | (Already identified by CPCAFE) | |
| Gap junction | 5.03×10−10 | [74] | Gap junction alterations in human cardiac disease |
| Prostate cancer | 6.04×10−10 | (Already identified by CPCAFE) | |
| Pancreatic cancer | 1.63×10−9 | — | — |
| Glutamatergic synapse | 2.02×10−8 | — | — |
| Endometrial cancer | 2.02×10−8 | (Already identified by CPCAFE) | |
| Long-term potentiation | 2.65×10−8 | — | — |
| Neurotrophin signaling pathway | 2.81×10−8 | — | — |
| Focal adhesion | 8.34×10−8 | (Already identified by CPCAFE) | |
| TGF-beta signaling pathway | 2.00×10−7 | (Already identified by CPCAFE) | |
| Endocytosis | 2.27×10−7 | — | — |
| Cholinergic synapse | 9.60×10−7 | — | — |
| Regulation of actin cytoskeleton | 1.33×10−6 | — | — |
| Colorectal cancer | 3.52×10−6 | (Already identified by CPCAFE) | |
| Salmonella infection | 5.65×10−6 | — | — |
| PI3K-Akt signaling pathway | 1.01×10−5 | — | — |
Pathways annotated as “Already identified as CPCAFE” are listed in Table 3.