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. 2015 May 29;13:170. doi: 10.1186/s12967-015-0526-9

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© Wozniak et al 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Sedation induced by fospropofol administered via a IV, b PO and c ID routes. The scoring system was on a 0–4 scale where 0 = alert and completely responsive, 1 = alert but less active and ‘wobbly’, 2 = awake but drowsy with periods of in-activity, 3 = generally sedated/inactive but readily arousable, 4 = unresponsive or unconscious. Sedative activity was assessed by blinded observers in 2–3 rats per treatment group.