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. 2015 May 29;13:170. doi: 10.1186/s12967-015-0526-9

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© Wozniak et al 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Pharmacokinetic parameters of AUC_last and C_max for fospropofol (b and a) and propofol (d and c) following oral administration of placebo or fospropofol at 200, 400, 600, 1,000 and 1,200 mg in human subjects (n = 10). Each subject received each of the doses. In general, dose proportional plasma concentrations of both fospropofol and propofol were observed. Data shown as mean ± SEM.