Table 2.
Mean (±SD) pharmacokinetic parameters of propofol following fospropofol administration in rats
| Route | Dose (mg/kg) | Cmax (µg/mL) | AUC(0−t) (µg h/mL) | AUC0−∞(µg h/mL) | T1/2 (h) | Fa (%) |
|---|---|---|---|---|---|---|
| IV | 5 | 0.29 (±0.04) | 0.12 (±0.02) | 0.14 (±0.03) | ND | ND |
| PO | 20 | 0.04 (±0.001) | 0.06 (±0.04) | 0.13 (±0.12) | 4.66 (±4.13) | 22.7 |
| PO | 100 | 0.53 (±0.08) | 1.21 (±0.2) | 1.96 (±0.6) | 4.13 (±1.12) | 70.5 |
| ID | 30 | 1.27 (±0.87) | 0.353 (±0.14) | 0.398 (±0.14) | 2.85 (±0.87) | 47.3 |
| ID | 100 | 5.84 (±2.29) | 3.57 (±0.57) | 3.95 (±0.48) | 2.32 (±0.73) | 141 |
aRatio of mean of AUC(0−∞) to reference treatment of 5 mg/kg IV fospropofol.