Table 1.
Baseline characteristics of study population
| Variable | Hb Genotype | Total | P-value | |
|---|---|---|---|---|
| SS | SC | |||
| (n = 142) | (n = 52) | (n = 194) | ||
| Age (years) | 20.77 ± 10.52 | 30.00 ± 13.49 | 23.25 ± 12.04 | 0.001 |
| Gender | 0.296 | |||
| Male | 66 (46.5) | 18 (34.6) | 84 (43.3) | |
| Female | 76 (53.5) | 34 (65.4) | 110 (56.7) | |
| Age group n (%) | 0.035 | |||
| <10 | 24 (16.9) | 2 (3.8) | 26 (13.4) | |
| 10-19. | 48 (33.8) | 10 (19.2) | 58 (29.9) | |
| 20-29 | 46 (32.4) | 16 (30.8) | 62 (32.0) | |
| 30-39 | 14 (9.9) | 14 (26.9) | 28 (14.4) | |
| ≥40 | 10 (7.0) | 10 (19.2) | 20 (10.3) | |
| Blood pressure (mmHg) | ||||
| SBP | 108.65 ± 8.45 | 113.92 ± 6.46 | 110.06 ± 8.27 | 0.005 |
| DBP | 65.89 ± 7.67 | 70.65 ± 8.84 | 67.16 ± 8.23 | 0.011 |
| BMI (Kg/m2) | 18.48 ± 12.91 | 19.84 ± 3.59 | 18.85 ± 11.19 | 0.599 |
| BMI n (%) | 0.002 | |||
| Underweight | 106 (74.6) | 20 (38.5) | 126 (64.9) | |
| Normal | 32 (22.5) | 24 (46.2) | 56 (28.9) | |
| Overweight | 4 (2.8) | 8 (15.4) | 12 (6.2) | |
| Proteinuria | 0.881 | |||
| Negative | 84 (59.2) | 34 (65.4) | 118 (60.8) | |
| Trace | 36 (25.4) | 14 (26.9) | 50 (25.8) | |
| 1+ | 8 (5.6) | 2 (3.8) | 10 (5.2) | |
| 2+ | 12 (8.5) | 2 (3.8) | 14 (7.2) | |
| 3+ | 2 (1.4) | 0 (0.0) | 2 (1.0) | |
| Serum Creatinine (μmol/l) | 46.19 ± 13.39 | 55.18 ± 12.72 | 48.60 ± 13.75 | 0.004 |
| eGFR, mL/min/1.73 m2 | 136.09 ± 24.70 | 119.19 ± 16.39 | 131.56 ± 23.90 | 0.002 |
| Haematological profile | ||||
| WBC x 103/mm3 | 11.83 ± 2.94 | 9.70 ± 4.31 | 11.26 ± 3.47 | 0.007 |
| RBC x106/mm3 | 2.83 ± 0.77 | 3.86 ± 1.10 | 3.11 ± 0.98 | 0.000 |
| HGB (g/dl) | 8.18 ± 1.45 | 14.87 ± 12.86 | 9.97 ± 11.61 | 0.011 |
| HCT (%) | 25.53 ± 12.98 | 28.46 ± 7.53 | 26.31 ± 19.20 | 0.508 |
| PLT x 103/mm3 | 318.14 ± 131.94 | 209.92 ± 79.58 | 289.13 ± 129.09 | 0.331 |
P <0.05 is significant, SBP = Systolic Blood Pressure, DBP = Diastolic Blood Pressure, BMI = Body Mass Index, eGFR = estimated Glomerular Filtration Rate, WBC = White Blood Cell, RBC = Red Blood Cell, HGB/Hb = Haemoglobin, HCT = Haematocrit, PLT = Platelet