Table 1.
Relationships between recurrence-associated pathways and clinicopathological variables in HBV-HCC
| Pathways-based subgroups | Recurrence analysis | ||||
|---|---|---|---|---|---|
| Univariate analysis | |||||
| Variables | Low risk | High risk | P-value 1 | Hazard ratio (95% CI) 2 | Log rank |
| p-value 3 | |||||
| Gender (Male/Female) | 52/14 | 65/11 | 0.406 | 0.563 (0.320 0.991) | 0.0439 |
| Age (<50 y/≥50 y) | 26/40 | 27/49 | 0.763 | 1.056 (0.706 1.577) | 0.790 |
| Platelet (<170 × 109/L/≥170 × 109/L) | 33/25 | 28/36 | 0.204 | 1.019 (0.675 1.538) | 0.928 |
| 4AST (<40 IU/L/≥40 IU/L) | 40/26 | 31/45 | 0.0287 | 1.096 (0.745 1.613) | 0.639 |
| 4ALT (<40 IU/L/≥40 IU/L) | 41/25 | 33/43 | 0.0397 | 1.003 (0.682 1.477) | 0.984 |
| Bilirubin (<1 mg/dL/≥1 mg/dL) | 44/22 | 42/34 | 0.224 | 1.050 (0.708 1.556) | 0.806 |
| 4AFP (<300 ng/mL /≥300 ng/mL) | 41/25 | 52/23 | 0.469 | 0.976 (0.644 1.480) | 0.912 |
| Child-Pugh (A/B,C) | 63/3 | 65/10 | 0.131 | 1.813 (0.967 3.401) | 0.0596 |
| UICC (I,II/III,IV) | 39/25 | 50/22 | 0.389 | 1.519 (1.015 2.273) | 0.0404 |
| Size (<3 cm/≥3 cm) | 14/52 | 12/64 | 0.538 | 2.178 (1.216 3.901) | 0.00726 |
| Number (Single/Multiple) | 56/10 | 64/10 | 0.972 | 1.874 (1.135 3.094) | 0.0125 |
| Necrosis (No/Yes) | 33/33 | 25/50 | 0.0664 | 1.565 (1.048 2.339) | 0.0273 |
| Edmondson’s grade (I,II/III,IV) | 45/19 | 45/27 | 0.435 | 1.273 (0.974 1.665) | 0.0764 |
| Vein invasion (Absent/Present) | 49/12 | 39/31 | 0.00501 | 1.787 (1.175 2.718) | 0.00594 |
| Lobular activity (No/Yes) | 39/25 | 18/56 | 2.879 × 10 −5 | 1.770 (1.166 2.685) | 0.00652 |
| Capsule (Absent/Present) | 47/19 | 64/11 | 0.0660 | 0.617 (0.374 1.017) | 0.05603 |
| Margin (<2 cm/≥2 cm) | 35/31 | 51/23 | 0.0794 | 0.836 (0.557 1.256) | 0.389 |
| Cirrhosis (Absent/Present) | 37/29 | 41/34 | 0.997 | 1.257 (0.853 1.852) | 0.245 |
| Recurrence-associated pathways | - | - | - | 2.843 (1.881 4.295) | 2.416 × 10 −7 |
| Multivariate analysis | |||||
| Recurrence-associated pathways | 3.220 (2.076 4.994) | 1.760 × 10 −7 | |||
| Number (Single/Multiple) | 1.839 (1.095 3.089) | 0.0212 | |||
| Size (<3 cm/≥3 cm) | 2.489 (1.288 4.808) | 0.00666 | |||
| Edmondson’s grade (I,II/III,IV) | 1.769 (1.159 2.701) | 0.00821 | |||
1 p-values were calculated using χ2 test.
2CI represents confidence interval.
3 p-values were calculated using the Cox Proportional Hazards Model.
4AST, aspartate aminotransferase; ALT, alanine aminotransferase; AFP, α-fetoprotein.
Bold data indicate statistically significant values (p<0.05).