Table 5.

Multivariate Cox model of overall survival to co-expression of p63 and CK5/6 (n = 67)

Variable	HR*	95% CI	P*
Age: >61 y versus ≤61 y†	2.694	1.035–7.011	0.042
Gender: Male versus female	0.117	0.011–1.305	0.081
Smoking history: Ever versus never	11.519	1.418–93.594	0.022
pT stage: pT2–4 versus pT1	2.601	0.983–6.879	0.054
Histological grade: Well/moderately versus poorly	0.454	0.171–1.205	0.113
p63+CK5/6 co-expression			0.002
Co-low expression versus co-overexpression	15.394	3.392–69.859	0.000
Partial overexpression versus co-overexpression	2.556	0.873–7.487	0.087

Co-overexpression, H scores_p63 > 150 and H scores_CK5/6 > 150; co-low expression, H scores_p63 ≤ 150 and H scores_CK5/6 ≤ 150; partial overexpression, H scores_p63 > 150 or H scores_CK5/6 > 150. *Statistical significance was calculated by the Cox proportional hazards model. †The median age of the entire population is indicated. CI, confidence interval; CK, cytokeratin; HR, hazard ratio.