Table 2.
Univariate analysis of clinical risk factors for ARP (grade 1–4) and SARP (grade 3–4)
| Factor group | Number of patients | ARP number of patients (%) | χ2-value | P-value | SARP number of patients (%) | χ2-value | P-value |
|---|---|---|---|---|---|---|---|
| Gender | 0.513 | 0.474 | 0.507 | ||||
| Male | 61 | 31 (50.82) | 6 (9.84) | ||||
| Female | 7 | 2 (28.57) | 0 (0) | ||||
| Age (year) | 3.224 | 0.073 | 11.11 | 1.000 | |||
| ≤65 | 59 | 27 (45.76) | 5 (8.47) | ||||
| >65 | 9 | 6 (66.67) | 1 | ||||
| Tumor site | 0.006 | 0.938 | 0.540 | 0.463 | |||
| Cervical | 2 | 0 (0) | 0 | ||||
| Upper thoracic | 10 | 7 (70) | 1 (10) | ||||
| Mid-thoracic | 24 | 10 (41.67) | 1 (4.17) | ||||
| Lower thoracic | 32 | 16 (50) | 4 (12.5) | ||||
| Stage | 2.368 | 0.124 | 0.011 | 0.918 | |||
| II | 27 | 10 (37.04) | 3 (11.11) | ||||
| III | 41 | 23 (56.10) | 3 (7.32) | ||||
| Chemotherapy | 0.84 | 0.772 | 0.711 | 0.399 | |||
| Yes | 40 | 20 (50) | 2.667 | 0.102 | 10 (25.00) | 0.327 | 0.567 |
| TP | 25 | 15 (60) | 7 (28) | ||||
| FP | 15 | 5 (33.33) | 3 (20) | ||||
| No | 28 | 13 (46.43) | 0.772 | 1 (3.57) | |||
| Smoking | 0.191 | 0.662 | 0.000 | 1.000 | |||
| Yes | 52 | 26 (50) | 5 (9.62) | ||||
| No | 16 | 7 (43.75) | 1 (6.25) | ||||
| History of respiratory system | 3.552 | 0.059 | 1.472 | 0.225 | |||
| Yes | 15 | 11 (73.33) | 3 (20.00) | ||||
| No | 53 | 22 (41.51) | 3 (5.66) | ||||
| Pulmonary infection in RT | 7.520 | 0.006 | 3.153 | 0.076 | |||
| Yes | 11 | 10 (90.91) | 3 (27.27) | ||||
| No | 57 | 23 (40.35) | 3 (5.26) |
ARP, acute radiation pneumonitis; FP regimen, cisplatin + 5-Fu; RT, radiation therapy; SARP, severe acute radiation pneumonitis; TP regimen, paclitaxel + cisplatin.