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. 2015 Jan 7;6(1):43–48. doi: 10.1111/1759-7714.12139

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© 2014 The Authors. Thoracic Cancer published by Tianjin Lung Cancer Institute and Wiley Publishing Asia Pty Ltd.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Concentration of paclitaxel in the lung over time. Paclitaxel (3 mg/kg) was administered by either intravenous (IV) (solid line) or intrapleural (IP) (dotted line) injection. Approximately 100 mg of lung tissue was harvested from six rats in each group at the time points indicated. The concentration of paclitaxel was determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The mean ± standard deviation (SD) is shown for each time point. , IV; , IP.

Inline graphic — Concentration of paclitaxel in the lung over time. Paclitaxel (3 mg/kg) was administered by either intravenous (IV) (solid line) or intrapleural (IP) (dotted line) injection. Approximately 100 mg of lung tissue was harvested from six rats in each group at the time points indicated. The concentration of paclitaxel was determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The mean ± standard deviation (SD) is shown for each time point. , IV; , IP.