Table 1.
Principle characteristics of included studies
| Study | Year | Country | Patients(n) | Mean age (years) | Gender (M/F) | Study design | Patient enrollment | Histology Ademo/squamos/other | N stage N0/N1/N2/N3 | Data type | Reference test |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Ohno et al.38 | 2004 | Japan | 110 | 64 (36–82) | 68/42 | prospective | consecutive | 85/18/7 | ND | Per-patient basedPer-lymph node based | Pathological analysis (mediastinoscopy or thoracotomy) |
| Ohno et al.39 | 2007 | Japan | 115 | 68 (35–81) | 59/56 | prospective | consecutive | 96/13/6 | 72/32.10/1 | Per-patient basedPer-lymph node based | Pathological analysis (mediastinoscopy or thoracotomy) |
| Kim et al.40 | 2008 | Korea | 113 | 61 (34–82) | 91/22 | prospective | consecutive | 58/41/14 | 62/23/24/4 | Per-lymph node based | Pathological analysis (mediastinoscopy or thoracotomy) |
| Hasegawa et al.41 | 2008 | Japan | 42 | 66 (41–83) | 30/12 | prospective | consecutive | ND | 34/3/5/0 | Per-patient based | Pathological analysis (thoracotomy) |
| Nomori et al.42 | 2008 | Japan | 88 | 70 (38–82) | 47/41 | prospective | ND | 67/18/3 | 71/9/8/0 | Per-lymph node based | Pathological analysis (thoracotomy) |
| Yi et al.43 | 2008 | Korea | 165 | 61 (34–82) | 125/40 | prospective | consecutive | 86/59/20 | 79/26/33/12 | Per-patient based | Pathological analysis (mediastinoscopy or thoracotomy or PCNA) |
| Nakayama et al.44 | 2010 | Japan | 70 | 68 (48–82) | 38/32 | retrospective | ND | 52/18/0 | 54/9/7/0 | Per-patient based | Pathological analysis (thoracotomy) |
| Ohno et al.45 | 2011 | Japan | 250 | 73 (61–83) | 136/114 | prospective | consecutive | 218/23/9 | 157/72/16/5 | Per-patient based | Pathological analysis (mediastinoscopy or thoracotomy) |
| Usuda et al.46 | 2011 | Japan | 63 | 68 (38–81) | 41/22 | ND | ND | 42/19/2 | 41/11/11/0 | Per-patient basedPer-lymph node based | Pathological analysis (thoracotomy) |
M/F, male/female, ND, not documented; PCNA, percutaneous needle aspiration biopsy.