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The specific inhibition rates of different cisplatin concentrations
| Cis (umol/L) | ||||||||
|---|---|---|---|---|---|---|---|---|
| 2.1 | 3.8 | 5.3 | 7.67 | 9 | 13 | 16.67 | 20 | |
| Inhibition rate | ||||||||
| Cis | 5.45 | 7.4 | 13.68 | 27.83 | 28.73 | 44.58 | 52.24 | 51.12 |
| Cis+TSA | 12.3 | 18.9 | 26.42 | 35.68 | 46.72 | 49.65 | 60.25 | 61.92 |
The cell apoptosis rate increased with the increase of cisplatin (Cis) concentration. Notably, trichostatin A (TSA) in combination with cisplatin caused a greater inhibitory effect on A549 cells than single-drug therapy (P < 0.05).
