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. 2015 May 29;5:10630. doi: 10.1038/srep10630

Figure 5. 4-Hydroxynonenal induced the activation of NRF2 in the corneal epithelium of rats.

Figure 5

a: Representative images of Western blot with anti-NRF2 antibody after topical administration of 4-Hydroxynonenal (100 μM) for 24 hours. b: Statistical analysis of Western blot results of NRF2. Data were presented as mean ± SEM; n = 3; *: p < 0.05. c, d, e: Statistical analysis of quantitative realtime PCR results of gene expressions of NRF2, NQO1 and GSTP after topical treatment of 4-Hydroxynonenal (250 μM) for 24 hours, respectively. Data were presented as mean ± SEM; n = 3; *: p < 0.05, ***: p < 0.001. (HNE=4-Hydroxynonenal).