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. 2015 May 29;5:9774. doi: 10.1038/srep09774

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Copyright © 2015, Macmillan Publishers Limited

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(A) HUVEC growth assay was performed to detect the HUVECs proliferation. CHIP overexpression significantly inhibited proliferation of HUVECs. Nevertheless, CHIP knockdown significantly promoted proliferation of HUVECs. (B) Representative pictures were taken in situ for tube formation in the supernatant of 786-O and OS-RC-2 cells (×100). The degree of tube formation was assessed as the number of tube. The average number of complete tubular structures formed by HUVECs from CHIP overexpression in the 786-O and OS-RC-2 cells led to 90% and 68% decrease, respectively; whereas increased 3.08- and 5.87-fold with knockdown of CHIP, respectively. All experiments were carried out in triplicate. Data are shown as mean ± s.e.m. ***P < 0.001, **P < 0.01, *P < 0.05.