Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 May 29;5:9774. doi: 10.1038/srep09774

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

(A) The secreted level of VEGF was determined by ELISA assay. VEGF secretion level was negatively regulated by CHIP in both 786-O and OS-RC-2 cells, respectively. All experiments were carried out in triplicate. (B) Representative WB analysis of the relative protein levels of VEGFR2 in CHIP restoration and control group for both 786-O and OS-RC-2 cell lines. VEGFR2 protein level was dramatically reduced after CHIP restoration. (C) Model of mechanism of CHIP inhibiting RCC angiogenesis. CHIP decreased the secreted level of VEGF, meanwhile increased the degradation of VEGFR2 and downregulated the protein level of VEGFR2 on cell membrane. Data are shown as mean ± s.e.m. *P < 0.05.