Table 1. Alignment of amino acid sequences of common cross-reactivity epitope of VP1 (e.g. EV71 VP145-53) from different enteroviruses.
| Virus | Species | Sequence | Reference | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| CA5* | Human enterovirus A | P | A | L | Q | A | A | E | T | G | ACT52615.1** |
| CA6* | Human enterovirus A | - | - | - | - | - | - | - | - | - | 44 |
| CA10* | Human enterovirus A | - | - | - | - | - | - | - | - | - | ADF43062.1 |
| CA16* | Human enterovirus A | - | - | - | - | - | - | - | - | - | 13 |
| EV71* | Human enterovirus A | - | - | - | - | - | - | - | I | - | 13 |
| CB3* | Human enterovirus B | - | - | - | T | - | - | - | - | - | AAD50446.1 |
| Echo4* | Human enterovirus B | - | N | - | T | - | V | - | - | - | AAF36390.1 |
| Echo6* | Human enterovirus B | - | - | - | T | - | - | - | - | - | AAA65044.1 |
| HPV1 | Human enterovirus C | - | - | - | T | - | V | - | - | - | 43 |
| HEV70 | Human enterovirus D | - | S | -- | N | - | V | - | - | - | 45 |
| HRV8 | Human rhinovirus A | - | - | - | D | - | - | - | - | - | 50 |
| HRV26 | Human rhinovirus B | - | - | - | T | - | N | - | - | - | 49 |
| HRVC | Human rhinovirus C | S | - | - | G | - | M | - | I | - | AEM44644.1 |
CA5:Human coxsackievirus A5, CA6:Human coxsackievirus A6, CA10:Human coxsackievirus A10, CA16:Human coxsackievirus A16, EV71:Human enterovirus 71, CB3:Human coxsackievirus B3, Echo4:Human echovirus 4, Echo6:Human echovirus 6; HPV1:Human poliovirus 1, HRV26:Human rhinovirus 26, HRV8:Human rhinovirus 8, HEV70:Human enterovirus 70, HRVC:Human rhinovirus C
The asterisks (*) represent causative agents of HFMD. The dash (-)indicates conserved amino acid. (**) indicates accession number of Genebank.