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Drawing of brain astrocytes by Santiago Ramón y Cajal. (A,B) Astrocytes, the darker cells in the drawing, contact both neurons, (C,D) the lighter cells, and (F) a blood vessel. As suggested by Ramón y Cajal, astrocytes are ideally situated to mediate signaling from neurons to blood vessels and to increase cerebral blood flow (CBF) in response to neuronal activity.
