TABLE 1.
Genetic interactions among smu-2, smu-1, and unc-52 mutations
| Genotypea | Developmental stage at onset of paralysis |
|---|---|
| unc-52(e669su250) | Adult |
| unc-52(e669) | Late L4 |
| unc-52(e1012) | Late L4 |
| unc-52(e444) | Early L4 |
| unc-52(e998) | Early L4 |
| unc-52(e1421) | Adult |
| smu-2(mn416) unc-52(e669su250) | None |
| smu-2(mn416) unc-52(e669) | Adult |
| smu-2(mn416) unc-52(e1012) | Adult |
| smu-2(mn416) unc-52(e444) | Early L4 |
| smu-2(mn416) unc-52(e998) | Early L4 |
| smu-2(mn416) unc-52(e1421) | Embryo; adultb |
| smu-1; unc-52(e669) | Adult |
| smu-1; unc-52(e1012) | Adult |
| smu-1; smu-2(mn416) unc-52(e669) | Adult |
| smu-1; smu-2(mn416) unc-52(e1012) | Adult |
a
Strains containing e669su250 were grown at 25°C. All others were grown at 20°C.
b
Thirty-seven percent of smu-2 unc-52(e1421) double mutants die as embryos, while 29% of the remaining larvae that hatch show abnormalities consistent with muscle defects. Those embryos that survive to adulthood with no or few abnormalities become uncoordinated at the adult stage in the same manner as unc-52(e1421) mutants.