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. 2015 Aug 18;57(6):649–658. doi: 10.1097/JOM.0000000000000413

TABLE 2. Agents Linked With Lymphohematopoietic Cancers and Their Presence in the Workplace.

Agent Classification* Cancer Inhalation Unit Risk per μg/m3 Agent Use in Workplace
IARC18 EPA19 NTP20 Process Agent Process Byproduct Quantified in Work Environment
Ionizing radiation (x- and γ-radiation) 1 Known Leukemia Yes Yes Yes
Benzene 1 Carcinogenic Known Leukemia and others No No No
1,3-Butadiene 1 Carcinogenic Known Leukemia and others No No No
1,2-dichloroethane 2B Likely carcinogenic Reasonably anticipated Lymphoma No Yes No
Ethylene oxide 1 Lymphoma No No No
Formaldehyde 1 Known Leukemia 4.6 × 10−6 (33) No No Yes§
Trichloroethylene 1 Carcinogenic Reasonably anticipated Lymphoma 2 × 10−6 (31) Yes No No

*EPA classifications include carcinogenic to humans (carcinogenic) and likely to be carcinogenic to humans (likely carcinogenic). NTP classifications include known to be a human carcinogen (known) and reasonably anticipated to be a human carcinogen (reasonably anticipated).

†Agent was measured above the limits of detection by the company and/or authors.

‡This inhalation unit risk is only for lymphoma, not kidney cancers, liver cancers, and lymphoma combined.

§The 75th percentile of formaldehyde concentrations in the Line C Tin Plating SEG was estimated to be 0.0053 ppm, compared with the OSHA PEL of 0.75 ppm and ACGIH TLV of 0.3 ppm.

‖Use of trichloroethylene was discontinued in 1995.

¶All monitoring by the authors found the concentration of TCE to be below the limit of detection.

EPA, Environmental Protection Agency; IARC, International Agency for Research on Cancer; NTP, National Toxicology Program; TCE, trichloroethylene.