TABLE 2. Agents Linked With Lymphohematopoietic Cancers and Their Presence in the Workplace.
Agent | Classification* | Cancer | Inhalation Unit Risk per μg/m3 | Agent Use in Workplace | ||||
---|---|---|---|---|---|---|---|---|
IARC18 | EPA19 | NTP20 | Process Agent | Process Byproduct | Quantified in Work Environment† | |||
Ionizing radiation (x- and γ-radiation) | 1 | Known | Leukemia | Yes | Yes | Yes | ||
Benzene | 1 | Carcinogenic | Known | Leukemia and others | No | No | No | |
1,3-Butadiene | 1 | Carcinogenic | Known | Leukemia and others | No | No | No | |
1,2-dichloroethane | 2B | Likely carcinogenic | Reasonably anticipated | Lymphoma | No | Yes | No | |
Ethylene oxide | 1 | Lymphoma | No | No | No | |||
Formaldehyde | 1 | Known | Leukemia | 4.6 × 10−6 (33) | No | No | Yes§ | |
Trichloroethylene | 1 | Carcinogenic | Reasonably anticipated | Lymphoma | 2 × 10−6 (31)‡ | Yes‖ | No | No¶ |
*EPA classifications include carcinogenic to humans (carcinogenic) and likely to be carcinogenic to humans (likely carcinogenic). NTP classifications include known to be a human carcinogen (known) and reasonably anticipated to be a human carcinogen (reasonably anticipated).
†Agent was measured above the limits of detection by the company and/or authors.
‡This inhalation unit risk is only for lymphoma, not kidney cancers, liver cancers, and lymphoma combined.
§The 75th percentile of formaldehyde concentrations in the Line C Tin Plating SEG was estimated to be 0.0053 ppm, compared with the OSHA PEL of 0.75 ppm and ACGIH TLV of 0.3 ppm.
‖Use of trichloroethylene was discontinued in 1995.
¶All monitoring by the authors found the concentration of TCE to be below the limit of detection.
EPA, Environmental Protection Agency; IARC, International Agency for Research on Cancer; NTP, National Toxicology Program; TCE, trichloroethylene.