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. 2015 Jun;25(6):792–801. doi: 10.1101/gr.185041.114

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© 2015 Kloosterman et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 3. — Overview of de novo and inherited indel classes and their formation mechanisms. (A) Proportion of de novo and inherited indels by class. Inherited indels exhibit a 2.3-fold enrichment in indels located in homopolymer runs (HR) and tandem repeats (TR) when compared to de novo indels, suggesting lower selective pressures in these regions. (B) Outline of a plausible seven-step process that could account for the formation of a complex de novo indel by SD-MMEJ.