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. 2015 Jun;25(6):792–801. doi: 10.1101/gr.185041.114

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© 2015 Kloosterman et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 4. — Mechanisms contributing to the formation of de novo SVs. (A) Overview of four SV formation mechanisms, including examples and observed counts for each of these. (L) Left flank, (R) right flank, (J) junction. (B) Schematic structure of a complex de novo interchromosomal SV involving an insertion of DNA from Chromosomes 3 and 19 into Chromosome 4. (TSD) Target site duplication.