Table 2.
Baseline clinical characteristics in 820 children on dialysis by ESA dose quartile
| No ESA (N=45) n (%) or mean (SD) |
Category 1 (N=157) n (%) or mean (SD) |
Category 2 (N=187) n (%) or mean (SD) |
Category 3 (N=195) n (%) or mean (SD) |
Category 4 (N=245) n (%) or mean (SD) |
p value | |
|---|---|---|---|---|---|---|
| Male | 29 (64) | 88 (56) | 107 (57) | 102 (25) | 119 (49) | 0.19b |
| Race | ||||||
| White | 23 (51) | 93 (59) | 114 (61) | 108 (55) | 141 (58) | 0.54b |
| Black | 16(36) | 44(28) | 59(32) | 59(30) | 80 (32) | |
| Other | 6 (13) | 20 (13) | 14 (7) | 28 (14) | 24 (10) | |
| Age (years) | 13.1 (5.5) | 13.2 (4.8) | 12.8 (4.8) | 12.8 (4.7) | 12.4 (5.1) | 0.56a |
| Cause of ESRD | ||||||
| Urological | 6 (13) | 54 (35) | 54 (29) | 59 (30) | 72 (29) | 0.01b |
| FSGS | 7 (16) | 30 (19) | 25 (13) | 24 (13) | 37 (15) | |
| SLE | 3 (7) | 2 (1) | 3 (2) | 16 (8) | 16 (7) | |
| Other | 29 (64) | 71 (45) | 105 (56) | 96 (49) | 120 (49) | |
| Dialysis modality | ||||||
| PD | 22 (49) | 121 (77) | 104 (56) | 94 (48) | 81 (33) | <0.001 |
| HD with AVF/AVG | 7 (16) | 24 (15) | 43 (23) | 46 (24) | 69 (28) | |
| HD with catheter | 16 (35) | 12 (8) | 40 (21) | 55 (28) | 95 (39) | |
| Deceased | 5 (11) | 7 (4) | 6 (3) | 12 (6) | 30 (12) | 0.002b |
| Kt/V | 1.5 (0.4) | 2.0 (0.8) | 1.9 (0.6) | 2.0 (1.4) | 1.9 (0.9) | 0.17a |
| Time on dialysis (years) | 2.5 (2.9) | 3.1 (3.4) | 3.3 (3.9) | 3.6 (4.3) | 3.9 (4.1) | 0.09a |
| Hemoglobin (g/dL) | 11.6 (2.0) | 11.74 (1.2) | 11.8 (1.5) | 11.4 (1.6) | 10.9 (1.7) | <0.001a |
| Albumin (g/dL) | 3.6 (0.7) | 3.8 (0.6) | 3.8 (0.6) | 3.7 (0.6) | 3.6 (0.6) | <0.001a |
*
Student’s t test;
**
Chi-squared analysis
| ESA U/kg/week | Category 1 | Category 2 | Category 3 | Category 4 |
| Erythropoietin | 0 to <100 | 100 to <200 | 200 to <350 | ≥350 |
| Darbepoetin | 0 to <0.49 | 0.49 to <1.0 | 1.0 to <1.5 | ≥1.5 |