Table 4. Change in mesenteric blood flow following topical TRPV4 activation in naïve and septic mice.

Baselines (BL), and responses to aerosolised vehicle (Veh; 10% DMSO in pre-warmed saline) and GSK1016790A (GSK; 1 µM) were recorded over sequential 5-min periods. Data are presented as mean percentage change in area under the curve over 5-min recording period. *p<0.05, **p<0.01, relative to vehicle response in the same mouse, paired 2-tailed Student’s T-test; ^#p<0.05 relative to corresponding response in naïve controls, 1-way ANOVA + Bonferroni post-hoc test (n = 5).

	Naive			LPS 24 h
	1 st order	2 nd order	3 rd order	1 st order	2 nd order	3 rd order
BL−Veh	-7.33 ± 3.10%	-8.39 ± 1.73%	-1.10 ± 0.32%	-3.00 ± 2.77%	-1.18 ± 1.51%	-2.22 ± 3.87%
Veh−GSK	-7.61 ± 1.30%	-8.46 ± 3.27%	-3.42 ± 2.05%	+12.11 ± 6.19%	+14.71 ± 6.70%* ,#	+11.73 ± 8.72%**