Table 3.

In vivo pharmacokinetic parameters of VST in rats after oral administration at a dose of 4 mg/kg

Parameter	VST (n=3)	F1 (n=3)	F2 (n=4)
AUC (μg⋅min/mL)	168.10±28.88	482.99±184.77	922.89±163.06#,+
Cmax (μg/mL)	0.72±0.28	0.84±0.07	4.72±1.72#,+
Tmax (min)	60 (45–60)	30 (15–60)	45 (30–45)
Relative bioavailability (%)	100	287	549

Notes: Data are presented as means ± standard deviation, except for median (ranges) for T_max; Tukey’s test was used as a post hoc test for the statistical analysis;

^#P<0.05, compared to VST group;

⁺P<0.05, compared to F1 group.

Abbreviations: AUC, total area under plasma VST concentration–time curve from time zero to infinity; C_max, peak plasma concentration; F1 and F2, solid dispersion formulations used in this study; min, minutes; T_max, time to reach C_max; VST, valsartan.