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Effects of AM251 on acute lethality following either paraoxon (PO) or chlorpyrifos oxon (CPO). Rats were treated with OP and then given vehicle or AM251 (3 mg/kg, ip) 30 minutes later. Cumulative lethality was recorded for 4 hours after OP exposure.
| OP | Lethality |
|---|---|
| PO (0.6 mg/kg, sc) | 2/14 |
| PO + AM 251 | 7/17* |
| CPO (12 mg/kg, sc) | 0/6 |
| CPO + AM 251 | 0/7 |
