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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Int J Hyperthermia. 2015 Feb 24;31(2):145–162. doi: 10.3109/02656736.2015.1007538

Figure 10.

Figure 10

Microtripsy resulting from a single principal negative half cycle exceeding the intrinsic threshold for cloud cavitation histotripsy. (A) A representative acoustic waveform for a 500 kHz histotripsy pulse measured in water with a fiber optic probe hydrophone (FOPH). (B) Cavitational bubble cloud and (C) corresponding lesion generated in a red blood cell (RBC) phantom using 500 kHz histotripsy pulses with an estimated peak negative pressure of 26.2 MPa (estimated using linear summation). (D) Demonstration of fine spatial resolution as evidenced in the phrase reading “M” (vertical scale bar 1 mm). (Produced using a 3 MHz transducer, and this figure is adapted from Lin et al. [14])