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(A) Histotripsy was applied to the prostate transcutaneously in anesthetized canine subjects. A transrectal ultrasound imaging probe provided real-time visualization of the prostate and cavitation bubble cloud during treatment. (B) H&E stained cross-section of the prostate four weeks after treatment. The targeted volume (devoid of debris) is seen within the glandular prostate communicating with the urethra.
