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(A) A boiling histotripsy transducer built to treat through large overlying tissue paths such as liver. (B) Three mechanical lesions generated at shallow depth in ex-vivo bovine liver tissue, showing the tadpole shape. (C) Lesions generated through different liver thicknesses showing consistent dimensions. Ultrasound was generated from the top of the frames. (D) In-situ pressure waveform determined using nonlinear derating method from characterization measurements in water [18, 88].
