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(A) Diagram of the experimental set-up for boiling histotripsy of subcutaneous B16 melanoma tumors in mice. (B) Frames of B-mode ultrasound recorded before and during boiling-histotripsy treatment of the tumor. (C) The dynamics of the tumor growth before and after boiling histotripsy or sham treatment (n = 4 per group). Although the treatment delayed the tumor growth, it did not affect the subsequent tumor growth rate.
