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. 2015 Mar 13;3(2):e00127. doi: 10.1002/prp2.127

Figure 2.

Figure 2

Citral, (+)-borneol, and camphor inhibit frog sciatic nerve CAPs in a manner resistant to a nonselective TRP antagonist ruthenium red (RR). (A and B) Effects of (+)-borneol (3 mmol/L) and camphor (5 mmol/L) on CAPs. (Aa and Ba) The chemical structures of (+)-borneol (Aa) and camphor (Ba). (Ab and Bb) Average time course of changes in CAP peak amplitudes following exposure to (+)-borneol (Ab) or camphor (Bb) for 20 min, relative to control. (Ca, Cb, and Cc) Average time course of changes in CAP peak amplitudes following treatment with RR (0.3 mmol/L) and then with citral (1 mmol/L; Ca), (+)-borneol (3 mmol/L; Cb) or camphor (5 mmol/L; Cc) together with RR (0.3 mmol/L), relative to that before drug treatment. In each of (Ca), (Cb), and (Cc), recordings in the right-hand side indicate a superimposition of CAPs in the control and in the presence of RR without (RR) and with citral (Ca), (+)-borneol (Cb) or camphor (Cc). (D) CAP peak amplitudes under the action of citral (1 mmol/L), (+)-borneol (3 mmol/L) or camphor (5 mmol/L) in the absence and presence of RR (0.3 mmol/L), relative to that just before the application of the TRP agonist. Value in parentheses denotes the number of nerve trunk examined. n.s., not significant; TRP, transient receptor potential; CAP, compound action potential.