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. 2015 Mar 13;3(2):e00127. doi: 10.1002/prp2.127

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© 2015 The Authors. Pharmacology Research & Perspectives published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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The CAP inhibitions produced by aroma oil compounds are specific to their chemical structures while being not related to their octanol–water partition coefficients (K_ows). (A) The chemical structures of aroma oil alcohols (a, b: chain alcohols having −OH at the end of the structure and at the other positions, respectively; c: cyclic alcohols) and their IC₅₀ values (as shown in parentheses) for CAP inhibitions. (B) A relationship between the IC₅₀ of aroma oil compound for CAP inhibition and the logarithum of its K_ow. Here, are plotted data of aroma oil compounds whose K_ows are available from ChemlDplus (see Table1). The straight line drawn through the data points is the least squares regression line (correlation coefficient: 0.24). CAP, compound action potential.